Table 1.
Characteristics of CRIC participants, stratified by baseline eGFR (in ml/min per 1.73 m2)
| eGFR <30 (n = 665) | eGFR 30 to <45 (n = 1326) | eGFR 45 to <60 (n = 1200) | eGFR ≥60 (n = 400) | P | |
|---|---|---|---|---|---|
| Demographic characteristics | |||||
| age (years) | 58.6 (11.3) | 59.7 (10.7) | 58.6 (10.4) | 51.5 (11.0) | <0.01 |
| male | 311 (46.8%) | 703 (53%) | 709 (59.1%) | 228 (57%) | <0.01 |
| non-white | 341 (51.3%) | 661 (49.8%) | 597 (49.8%) | 230 (57.5%) | 0.2 |
| Hispanic | 54 (8.1%) | 57 (4.3%) | 39 (3.3%) | 18 (4.5%) | <0.01 |
| education | <0.01 | ||||
| less than high school | 152 (22.9%) | 262 (19.8%) | 152 (12.7%) | 32 (8.0%) | |
| high school graduate | 143 (21.5%) | 279 (21.0%) | 200 (16.7%) | 70 (17.5%) | |
| some college | 197 (29.6%) | 395 (29.8%) | 369 (30.8%) | 139 (34.8%) | |
| college graduate | 173 (26.0%) | 390 (29.4%) | 479 (39.9%) | 158 (39.6%) | |
| Prevalent conditions | |||||
| diabetes | 349 (20.9%) | 691 (41.4%) | 500 (29.9%) | 131 (7.8%) | <0.01 |
| hypertension | 612 (92.0%) | 1201 (90.6%) | 996 (83.1%) | 268 (67.2%) | <0.01 |
| history of elevated cholesterol | 583 (87.7%) | 1114 (84%) | 957 (79.8%) | 271 (67.8%) | <0.01 |
| smoking (ever vs. never) | 405 (60.9%) | 758 (57.2%) | 655 (54.6%) | 191 (47.8%) | <0.01 |
| stroke | 78 (11.7%) | 147 (11.1%) | 120 (10.0%) | 18 (4.5%) | <0.01 |
| coronary heart disease | 169 (25.4%) | 324 (24.4%) | 257 (21.4%) | 52 (13.0%) | <0.01 |
| peripheral arterial disease | 74 (11.1%) | 103 (7.8%) | 60 (5.0%) | 11 (2.8%) | <0.01 |
| Anthropometric and laboratory measures | |||||
| eGFR (ml/min per 1.73 m2) | 25.0 (3.4) | 37.9 (4.2) | 51.7 (4.2) | 67.7 (7.6) | – |
| systolic blood pressure (mmHg) | 130.5 (23.6) | 129.0 (22.5) | 126.0 (20.6) | 123.5 (20.0) | <0.01 |
| diastolic blood pressure (mmHg) | 69.9 (13.3) | 70.8 (12.7) | 71.7 (12.5) | 74.8 (12.8) | <0.01 |
| total cholesterol (mg/dl) | 183.4 (51.7) | 182.9 (44.7) | 183.0 (41.8) | 183.52 (39.2) | 0.9 |
| hemoglobin (g/dl) | 11.9 (1.7) | 12.5 (1.7) | 13.1 (1.7) | 13.4 (1.6) | <0.01 |
| serum albumin (g/dl) | 3.9 (0.5) | 3.9 (0.5) | 4.0 (0.4) | 4.1 (0.4) | <0.01 |
| log C-reactive protein | 1.1 (1.3) | 1.1 (1.3) | 0.9 (1.2) | 0.6 (1.2) | <0.01 |
| total homocysteine (μmol/L) | 19.0 (6.9) | 15.9 (5.8) | 13.3 (5.0) | 10.9 (4.0) | <0.01 |
| albuminuria (mg/day) | <0.01 | ||||
| <30 mg/day | 123 (8.7%) | 450 (31.9%) | 599 (42.4%) | 240 (17%) | |
| 30 to 299 mg/day | 200 (32.2%) | 364 (28.7%) | 302 (26.4%) | 79 (21.4%) | |
| 300 to 999 mg/day | 121 (19.5%) | 227 (17.9%) | 141 (12.3%) | 30 (8.1%) | |
| ≥1000 mg/day | 178 (28.6%) | 226 (17.8%) | 101 (8.8%) | 20 (5.4%) |
The results are presented as the means (standard deviation) or frequency (N, %).