Table 3.
Effects of weight reduction in obese patients on metabolic variables and renal markers
| Group Unsuccessful in Weight Reduction |
Group Successful in Weight Reduction |
|||
|---|---|---|---|---|
| Before | 3 Months | Before | 3 Months | |
| Male/female | 56/72 | 25/29 | ||
| Age (years) | 53.4 ± 1.2 | 50.4 ± 2.1 | ||
| BMI (kg/m2) | 30.7 ± 0.5 | 30.7 ± 0.5 | 32.1 ± 0.7 | 29.7 ± 0.7a |
| Waist circumference (cm) | 99.5 ± 1.3 | 99.1 ± 1.2 | 102 ± 1.6 | 96.3 ± 2.2a |
| Systolic blood pressure (mmHg) | 140 ± 1.5 | 137 ± 1.4 | 137 ± 2.7 | 130 ± 2.1a |
| Diastolic blood pressure (mmHg) | 81.2 ± 1.1 | 80.7 ± 1.0 | 81.4 ± 2.5 | 76.3 ± 1.3 |
| Fasting plasma glucose (mg/dl) | 135 ± 4.4 | 134 ± 4.3 | 142 ± 7.6 | 129 ± 7.3b |
| HbA1c (%) | 6.85 ± 0.1 | 6.83 ± 0.1 | 6.98 ± 0.2 | 6.45 ± 0.2a |
| IRI (mU/ml) | 18.2 ± 1.8 | 20.2 ± 2.7 | 22.3 ± 5.7 | 21.6 ± 10 |
| Triglyceride (mg/dl) | 162 ± 8.2 | 161 ± 6.8 | 170 ± 12 | 153 ± 12 |
| HDL-C (mg/dl) | 55.1 ± 1.2 | 53.3 ± 1.0 | 54.0 ± 1.8 | 53.5 ± 1.7 |
| LDL-C (mg/dl) | 122 ± 3.0 | 123 ± 0.5 | 123 ± 4.3 | 113 ± 3.5a |
| Leptin (ng/ml) | 13.9 ± 1.1 | 14.6 ± 1.0 | 13.6 ± 2.0 | 12.2 ± 2.3 |
| Adiponectin (μg/ml) | 7.11 ± 0.4 | 7.73 ± 0.5 | 6.76 ± 0.5 | 7.98 ± 0.5b |
| CRP (μg/ml) | 1.39 ± 0.2 | 1.17 ± 0.1 | 1.32 ± 0.2 | 1.00 ± 0.1 |
| eGFR | 72.2 ± 2.7 | 70.6 ± 2.3 | 71.6 ± 3.5 | 72.1 ± 3.7 |
| S-CysC (mg/L) | 0.84 ± 0.03 | 0.85 ± 0.03 | 0.81 ± 0.04 | 0.84 ± 0.05 |
| UACR (mg/g·Cr) | 116 ± 45 | 132 ± 50 | 158 ± 72 | 130 ± 58 |
| UCCR | 0.78 ± 0.11 | 0.70 ± 0.08 | 0.83 ± 0.17 | 0.66 ± 0.16a |
| U-B2MG (μg/L) | 165 ± 36 | 229 ± 92 | 184 ± 68 | 129 ± 39 |
| U-NAG (U/L) | 4.70 ± 0.5 | 4.02 ± 0.6 | 4.08 ± 1.1 | 2.96 ± 0.4 |
| CAVI | 7.92 ± 0.1 | 7.89 ± 0.2 | 7.75 ± 0.3 | 7.42 ± 0.3a |
The data are expressed as the means ± SEM.
a
P < 0.01 versus before determined by a two-tailed paired t test.
b
P < 0.05 versus before determined by a two-tailed paired t test.