VP in association with markers of disease severity in ADPKD (males ▴ and —; females ○ and – –). On the left, associations between copeptin and TRV (upper left; overall: R = 0.47, P < 0.001; males: R = 0.37, P = 0.006; females: R = 0.37, P = 0.01) and 24-hour UAE (lower left; overall: R = 0.39, P < 0.001; males: R = 0.30, P = 0.03; females: R = 0.29, P = 0.07). On the right, associations between log copeptin and ERBF (upper right; overall R = −0.52, P < 0.001; males: R = −0.57, P < 0.001; females: R = −0.61, P < 0.001) and GFR (lower right; overall R = −0.58, P < 0.001, males: R = −0.58, P < 0.001; females: R = −0.61, P < 0.001).