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. Author manuscript; available in PMC: 2011 Mar 9.
Published in final edited form as: Psychopharmacology (Berl). 2010 Sep 9;212(4):687–697. doi: 10.1007/s00213-010-2001-x

Fig. 5.

Fig. 5

Correlation between the reactivation potencies (log EC50, Fig. 4) and affinities (log Ki) of non-inactivating drugs at the h5-HT7 receptor. The high correlation observed (r2=0.95) indicates that the reactivation of risperidone-inactivated h5-HT7 receptors is due to the binding of the reactivating drugs to the orthosteric binding site of the h5-HT7 receptor despite the presence of wash-resistant [3H]risperidone binding to the orthosteric site. Membrane homogenate Ki values (nanomolar): SB269970, 2±0.6; mesulergine, 18±3; cyproheptadine, 24±5; clozapine, 30±5; mianserin, 64±5, ICI169369, 393±54