Fig. 8.

Intact cell affinities of six antagonists for the h5-HT₇ receptors not pseudo-irreversibly blocked by risperidone. Cells were exposed to 1 μM risperidone or buffer and washed, and radioligand binding studies were conducted on the untreated and risperidone-exposed h5-HT₇ receptors on intact cells. [³H] 5-HT (2 nM) binding was used to radiolabel intact cells. Results are the means±SEM of three independent experiments performed in triplicate. Two-way ANOVA with Bonferroni’s post-tests shows significant differences (p<0.05) between the control and risperidone-treated groups for SB269970 and mianserin only, but not for clozapine, mesulergine, cyproheptadine, or ICI169369