Table 1.

Patients at high risk of bleeding and patients who need careful evaluation for possible risk of bleeding

Patients at high risk of bleeding	Patients to be carefully evaluated for possible risk of bleeding
Prolonged PT (INR > 1.5)	Prolonged APTT (except antiphospholipid antibody syndrome)
Thrombocytopenia < 50,000/µl
Known bleeding diathesis	Severe CRF (creatinine clearance < 30 ml/min)
Chronic liver disease with prior bleeding episodes	Family or personal history of major bleeding
Multiple trauma (ISS ≥ 15)	Concomitant use of drugs affecting hemostasis (e.g., antiplatelet drugs, anti-inflammatory drugs)

PT prothrombin time,INR International normalized ratio,ISS injury severity score,APTT antiplatelet treatment,CRF chronic renal failure