Fig. 1.

A Normal mitotic HeLa cell (a). The major categories of PCC phenotype: S-PCC (b), G2-PCC (c), and chromosome segregation defects (d). Representative nucleus displaying signs of apoptosis (e). HeLa cells treated with hydroxyurea were stained with DAPI dye for DNA. Micronucleus formation (f; arrows), were found significantly increased in comparison with the control. Scale bars = 10 μm. (B) Mitotic indices (%) and % of cell nuclei displaying signs of apoptosis evaluated for HeLa cells (the cells were treated as described in the figure legend). (C) Quantification of PCC phenotypes in HeLa cells