Skip to main content
. 2011 Mar;66(3):351–359. doi: 10.1111/j.1398-9995.2010.02483.x

Figure 4.

Figure 4

Long-term exposure of tape-stripped mouse skin to Staphylococcus aureus extracellular vesicles (EV) enhances the production of IgE. Evaluation (n = 5 per treatment group) was performed 48 h after the final application of S. aureus EV (5 μg) (performed three times a week for 8 weeks) to tape-stripped skin. *P < 0.05; **P < 0.01; ***P < 0.001. (A) Skin histology [H&E staining; magnification, ×200 (upper panel) and ×400 (lower panel)]. Arrowheads identify eosinophils. (B) Histological analysis of epidermal thickness and numbers of eosinophils and mast cells infiltrating the dermis. (C) Levels of IL-17 in supernatants from S. aureus EV-treated cells from skin-draining lymph nodes. (D) Serum levels of total IgG1 and total IgE.