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Mutation of the L4 Spi-B-binding site in the Mad-4 promoter/enhancer is sufficient to abrogate JCV activity in PDA. The fraction of T antigen-positive cells as a fold change over the wild-type Mad-4 plasmid for archetype, Mad-1, Mad-4, L5 mutant Mad-4, L4 mutant Mad-4 or L5/L4 mutant Mad-4 plasmids is represented along with sd. An asterisk denotes the following statistically significant change in value. Archetype, P=0.039 ; L5/L4 mutant, P=0.039 ; L4 mutant, P=0.039.
