Table 1.
Transgenic line | CWD brain | CWD spinal cord | BSE brain |
---|---|---|---|
Attack rate* | Attack rate* | Attack rate* | |
129VV Tg152 | 0/8† | 0/6‡ | 10/26 |
129MM Tg45 | 0/7§ | 0/6|| | 9/12 |
129MM Tg35 | 0/9¶ | 0/5# | 14/49 |
*All mice were inoculated with 30 μl of 1 % (w/v) tissue homogenate. Attack rate is defined as the total number of both clinically affected and subclinically infected mice as a proportion of the number of inoculated mice. Subclinical prion infection was assessed by sodium phosphotungstic acid precipitation of 250 μl 10 % brain homogenate and analysis for PrPSc by immunoblotting and/or immunohistochemical examination of brain.
†Mice culled at 274, 316, 321, 436, 517, 517, 587 and 781 days post-inoculation.
‡Mice culled at 354, 364, 463, 541, 704 and 724 days post-inoculation.
§Mice culled at 322, 322, 395, 400, 529, 656 and 736 days post-inoculation.
||Mice culled at 275, 345, 396, 462, 462 and 532 days post-inoculation.
¶Mice culled at 341, 559, 662, 662, 680, 707, 707, 747 and 748 days post-inoculation.
#Mice culled at 392, 414, 542, 699 and 732 days post-inoculation.