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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Mol Microbiol. 2010 Oct 29;79(1):133–148. doi: 10.1111/j.1365-2958.2010.07431.x

Table 2.

Genes more than two-fold down-regulated in pafA, mpa, and mpa607 mutants as determined by microarray analysisa, sorted by locus.

Locus Gene Nameb mpa607c mpac pafAc
Rv0140 hypothetical protein 0.40 0.56 0.48
Rv0654 PROBABLE DIOXYGENASE 0.34 0.41 0.49
Rv0765c PROBABLE OXIDOREDUCTASE 0.48 0.65 0.54
Rv0766c PROBABLE CYTOCHROME P450 123 (cyp123) 0.41 0.47 0.54
Rv0767c hypothetical protein 0.28 0.49 0.47
Rv0768 PROBABLE ALDEHYDE DEHYDROGENASE NAD DEPENDENT ALDA (aldA) 0.38 0.48 0.46
Rv0769 PROBABLE DEHYDROGENASE/REDUCTASE 0.47 0.53 0.51
Rv0790c hypothetical protein 0.45 0.58 0.50
Rv0791c hypothetical protein 0.39 0.52 0.39
Rv0792c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) 0.37 0.55 0.50
Rv0793 hypothetical protein 0.47 0.67 0.56
Rv0847 PROBABLE LIPOPROTEIN (lpqS) 0.24 0.52 0.33
Rv0848 POSSIBLE CYSTEINE SYNTHASE A (cysK2) 0.32 0.56 0.42
Rv0850 PUTATIVE TRANSPOSASE (FRAGMENT) 0.33 0.70 0.39
Rv1169c PE FAMILY PROTEIN (pe11) 0.41 0.66 0.54
Rv1218c PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER 0.32 0.67 0.40
Rv1285 PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 (cysD) 0.24 0.41 0.35
Rv1286 PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC (cysN) 0.30 0.54 0.37
Rv1287 hypothetical protein 0.44 0.67 0.44
Rv2466c hypothetical protein 0.34 0.49 0.45
Rv2517c hypothetical protein 0.43 0.52 0.54
Rv2641 CADMIUM INDUCIBLE PROTEIN (cadI) 0.47 0.63 0.50
Rv2642 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY) 0.39 0.53 0.46
Rv2873 CELL SURFACE LIPOPROTEIN (mpt83) 0.46 0.52 0.54
Rv2875 MAJOR SECRETED IMMUNOGENIC PROTEIN (mpt70) 0.40 0.42 0.41
Rv2912c PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) 0.26 0.42 0.25
Rv2913c POSSIBLE D-AMINO ACID AMINOHYDROLASE (D-AMINO ACID HYDROLASE) 0.23 0.41 0.36
Rv2962c POSSIBLE GLYCOSYL TRANSFERASE 0.41 0.64 0.51
Rv2963 PROBABLE INTEGRAL MEMBRANE PROTEIN 0.25 0.60 0.38
Rv2987c PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) (leuD) 0.56 0.40 0.43
Rv3249c POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) 0.34 0.46 0.42
Rv3250c PROBABLE RUBREDOXIN (rubB) 0.37 0.50 0.46
Rv3251c PROBABLE RUBREDOXIN (rubA) 0.34 0.50 0.47
Rv3252c PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE (alkB) 0.30 0.45 0.43
Rv3269 hypothetical protein 0.40 0.65 0.59
Rv3270 PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C (ctpC) 0.37 0.63 0.51
Rv3463 hypothetical protein 0.37 0.53 0.48
MT0196 mymT 0.36 0.71 0.47
a

Dye-flipped experiments were performed in duplicate for each mutant compared to WT. Statistical analysis was determined by SAM analysis between all conditions.

b

Functional annotations are taken from the Mtb strain H37Rv complete genome sequence (www.jcvi.org)

c

Numbers represent expression in the mutant strains relative to WT Mtb in 7H9 media grown to early stationary phase

d

In bold are genes with the palindrome.

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