Table 2.
Genes more than two-fold down-regulated in pafA, mpa, and mpa607 mutants as determined by microarray analysisa, sorted by locus.
Locus | Gene Nameb | mpa607c | mpac | pafAc |
---|---|---|---|---|
Rv0140 | hypothetical protein | 0.40 | 0.56 | 0.48 |
Rv0654 | PROBABLE DIOXYGENASE | 0.34 | 0.41 | 0.49 |
Rv0765c | PROBABLE OXIDOREDUCTASE | 0.48 | 0.65 | 0.54 |
Rv0766c | PROBABLE CYTOCHROME P450 123 (cyp123) | 0.41 | 0.47 | 0.54 |
Rv0767c | hypothetical protein | 0.28 | 0.49 | 0.47 |
Rv0768 | PROBABLE ALDEHYDE DEHYDROGENASE NAD DEPENDENT ALDA (aldA) | 0.38 | 0.48 | 0.46 |
Rv0769 | PROBABLE DEHYDROGENASE/REDUCTASE | 0.47 | 0.53 | 0.51 |
Rv0790c | hypothetical protein | 0.45 | 0.58 | 0.50 |
Rv0791c | hypothetical protein | 0.39 | 0.52 | 0.39 |
Rv0792c | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) | 0.37 | 0.55 | 0.50 |
Rv0793 | hypothetical protein | 0.47 | 0.67 | 0.56 |
Rv0847 | PROBABLE LIPOPROTEIN (lpqS) | 0.24 | 0.52 | 0.33 |
Rv0848 | POSSIBLE CYSTEINE SYNTHASE A (cysK2) | 0.32 | 0.56 | 0.42 |
Rv0850 | PUTATIVE TRANSPOSASE (FRAGMENT) | 0.33 | 0.70 | 0.39 |
Rv1169c | PE FAMILY PROTEIN (pe11) | 0.41 | 0.66 | 0.54 |
Rv1218c | PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER | 0.32 | 0.67 | 0.40 |
Rv1285 | PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 (cysD) | 0.24 | 0.41 | 0.35 |
Rv1286 | PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC (cysN) | 0.30 | 0.54 | 0.37 |
Rv1287 | hypothetical protein | 0.44 | 0.67 | 0.44 |
Rv2466c | hypothetical protein | 0.34 | 0.49 | 0.45 |
Rv2517c | hypothetical protein | 0.43 | 0.52 | 0.54 |
Rv2641 | CADMIUM INDUCIBLE PROTEIN (cadI) | 0.47 | 0.63 | 0.50 |
Rv2642 | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY) | 0.39 | 0.53 | 0.46 |
Rv2873 | CELL SURFACE LIPOPROTEIN (mpt83) | 0.46 | 0.52 | 0.54 |
Rv2875 | MAJOR SECRETED IMMUNOGENIC PROTEIN (mpt70) | 0.40 | 0.42 | 0.41 |
Rv2912c | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) | 0.26 | 0.42 | 0.25 |
Rv2913c | POSSIBLE D-AMINO ACID AMINOHYDROLASE (D-AMINO ACID HYDROLASE) | 0.23 | 0.41 | 0.36 |
Rv2962c | POSSIBLE GLYCOSYL TRANSFERASE | 0.41 | 0.64 | 0.51 |
Rv2963 | PROBABLE INTEGRAL MEMBRANE PROTEIN | 0.25 | 0.60 | 0.38 |
Rv2987c | PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) (leuD) | 0.56 | 0.40 | 0.43 |
Rv3249c | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) | 0.34 | 0.46 | 0.42 |
Rv3250c | PROBABLE RUBREDOXIN (rubB) | 0.37 | 0.50 | 0.46 |
Rv3251c | PROBABLE RUBREDOXIN (rubA) | 0.34 | 0.50 | 0.47 |
Rv3252c | PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE (alkB) | 0.30 | 0.45 | 0.43 |
Rv3269 | hypothetical protein | 0.40 | 0.65 | 0.59 |
Rv3270 | PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C (ctpC) | 0.37 | 0.63 | 0.51 |
Rv3463 | hypothetical protein | 0.37 | 0.53 | 0.48 |
MT0196 | mymT | 0.36 | 0.71 | 0.47 |
Dye-flipped experiments were performed in duplicate for each mutant compared to WT. Statistical analysis was determined by SAM analysis between all conditions.
Functional annotations are taken from the Mtb strain H37Rv complete genome sequence (www.jcvi.org)
Numbers represent expression in the mutant strains relative to WT Mtb in 7H9 media grown to early stationary phase
In bold are genes with the palindrome.