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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Trends Cell Biol. 2010 Nov 8;21(2):122–131. doi: 10.1016/j.tcb.2010.10.003

Figure 2.

Figure 2

Regulation of endocytic transport by EHD proteins, Rabs and their effectors. Internalised receptors reach the sorting or early endosome (EE) and are trafficked through one of at least four pathways. Receptors slated for degradation are sorted to EE microdomains containing EHD4, Rab5 and Rabenosyn-5 and transported to late endosomes and lysosomes. Other internalised proteins, such as the Shiga toxin, are transported from EE to the Golgi via an EHD3 and/or EHD1-dependent retrograde pathway. Receptors that recycle back to the plasma membrane can do so directly from EE in a poorly defined manner that requires the function of Rab4 (Fast recycling). Alternatively, many receptors are first directed to the perinuclear endocytic recycling compartment and then shuttled to the plasma membrane (Slow recycling). Slow recycling requires the sequential function of multiple regulators including Rab5, Rab11, Rab8a their effectors (Rabenosyn-5, Rab11-FIP2 and MICAL-L1, respectively), and EHD proteins.