Table 1.

Relationship of EHD proteins to human disease.

EHD Protein	Disease or condition	Aberrancy phenotype	transcript or protein	Fold increase or decrease	Reference
EHD1	Pseudoexfoliation glaucoma	enhanced levels of serum antibodies	N/A	N/A	[73]
EHD1	Apergillus fumigatus infection	enhanced EHD1 expression in monocytes	transcript	1.5–2 fold increase	[74]
EHD1	Metastatic ability of well-differentiated pancreatic endocrine neoplasms	decreased expression	transcript	3.1 fold decrease	[75]
EHD1	Sickle cell disease	decreased expression	protein	not given	[76]
EHD1	Aeromonas hydrophila cytotoxic enterotoxin induced-genes	increased expression in macrophages	transcript	3–4 fold increase	[77]
EHD1	Plasmodium falciparum infected erythrocytes	increased expression in erythrocytes	transcript	4.9 fold increase	[78]
EHD1	Prostate cancer	secreted from exosomes of prostate cancer cells	protein	N/A	[79]
EHD1	Cutaneous T cell lymphoma	increased expression in lesion	transcript	1.5 fold increase	[80]
EHD1–4	Glioma	gene loss proposed	N/A	N/A	[81]
EHD2	Diabetes mellitus-associated bladder dysfunction	decreased EHD2 expression	protein	1.5 fold decrease	[82]
EHD2	Primary pigmented nodular adrenocortical disease	increased EHD2 expression	transcript	0.19% expression compared to 0% in control	[83]
EHD3	Oral squamous cell carcinoma	decreased EHD3 expression	transcript	11.9 fold decrease	[84]
EHD3	Small-cell lung cancer	increased EHD3 expression	transcript	abundant increase (value not given)	[85]
EHD3	Acute myeloid leukemias	gene methylation	N/A	N/A	[86]
EHD4	Systemic onset juvenile idiopathic arthritis	increased EHD4 expression	transcript	0.8 fold increase	[87]