. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Diabetes Obes Metab. 2010 Oct;12(Suppl 2):116–125. doi: 10.1111/j.1463-1326.2010.01266.x

Table 2. Evidence for compartment-specific redox changes during normal and stressed conditions.

Following treatment with different stimuli as indicated, responses in subcellular compartments were measured by different techniques as discussed in the text. Redox response is indicated by + and no response is indicated by − sign. Compartments not measured are indicated by a blank space. Abbreviations: PM, plasma membrane: Cyto, cytoplasm; ER, endoplasmic reticulum; Mito, mitochondria; Nucl, nuclei. Where different responses occurred for redox components within the same compartment, respective redox sensitive components are given in parentheses. See text for additional details.

	Stimulus	PM	Cyto	ER	Mito	Nucl	Ref
Normal condition	EGF	+	+		-		[30]
	TNF-α			+	+		[32]
	IGF-1	+	-				[63]
Stressed condition	H₂O₂		-		+	-	[20]
	TBH		-		+	-	[20]
	Nuclear H₂O₂		-		-	+	[43]
	-Glc & -Gln		+	-	+		[18]
	+Cu; +Fe, or +Ni		+ (GSH) - (Trx1)		- (Trx2)		[44]
	+As; +Cd; or +Hg		- (GSH) + (Trx1)		+ (Trx2)		[44]
	Extracellular E_hCySS	+	-	-	+	-	[24]