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. Author manuscript; available in PMC: 2012 Jan 27.
Published in final edited form as: Neuron. 2011 Jan 27;69(2):273–286. doi: 10.1016/j.neuron.2010.12.022

Figure 4. Dynamic branches form clustered immature synapses.

Figure 4

(A–C) Distribution of synapses, color-coded to show their relative maturation, on 3D renderings of extending (A), retracting (B) and stable (C) dendrites. Immature synapses (cold colors) are preferentially located on dynamic branches; stable branches are studded with mature synapses (warm colors). (D) Synapses on stable dendritic branches are more mature than synapses on extended dendritic branches. (E) Maturation index of synapses contacting stable and extending branches compared to the distances between synapses (interbouton distance). Extended branches form clustered immature synapses. (F) Paired comparison of the maturation indices of synapses from the same axonal bouton contacting mHRP-positive and negative dendrites. Boutons contacting stable HRP-labeled dendrites also form contacts with relatively correlated maturation indices whereas boutons contacting extending HRP-labeled branches form contacts with heterogeneous maturation indices. Scale box is 1µm in A, 2µm in B and C.