Table 1.
Variable | Total Cohort | Subset with Radiographic Scores | ||||
---|---|---|---|---|---|---|
CLEAR I n=357 |
CLEAR II n=418 |
p value† | CLEAR I n=294 |
CLEAR II n=167 |
p value† | |
Age at enrollment, years, mean (SD) | 51.0 (13.2) | 56.9 (11.6) | 0.0103 | 50.6 (13.5) | 56.2 (10.8) | 0.0016 |
Age at RA onset, mean (SD) | 50.0 (13.2) | 45.0 (13.0) | 0.7035 | 49.6 (13.5) | 42.8 (12.4) | 0.2290 |
Gender (female), % | 82.4 | 87.3 | 0.0533 | 82.7 | 84.4 | 0.6228 |
Disease duration at enrollment, months, median (IQ 25–75) |
11.5 (6.3–17.9) | 108.0 (40.0–213.0) | <0.0001 | 12.1 (6.8–19.1) | 126.0 (61.0–223.0) | <0.0001 |
Education, % | 0.5613 | 0.4284 | ||||
Elementary | 7.8 | 5.7 | 8.0 | 5.0 | ||
High school | 51.2 | 49.4 | 50.2 | 52.2 | ||
College | 36.7 | 40.0 | 38.0 | 36.5 | ||
Graduate and postgraduate | 4.3 | 4.9 | 3.8 | 6.3 | ||
Poverty‡, % | 31.0 | 33.7 | 0.4409 | 30.9 | 30.6 | 0.9426 |
Family history of RA§ % | 31.4 | 38.8 | 0.0321 | 29.9 | 43.1 | 0.0043 |
Smoking¶ | ||||||
current % | 29.1 | 24.2 | 0.1180 | 28.9 | 23.4 | 0.1958 |
ever % | 52.7 | 55.0 | 0.5107 | 52.7 | 56.3 | 0.4602 |
Alcohol¶ | ||||||
current % | 16.8 | 22.5 | 0.0482 | 16.7 | 23.4 | 0.0791 |
ever % | 65.8 | 73.2 | 0.0257 | 66.7 | 73.7 | 0.1184 |
The CLEAR Registry is still actively collecting radiographs at 36 months and 60 months disease duration in CLEAR I and at study entry in CLEAR II. Thus, radiographic scores are not available for all subjects at the present time;
p-value calculated by Chi-square or Wilcoxon Rank-sum;
Poverty as per the US Federal government guidelines adjusted for the number of persons in the household;
First degree (including mother, father, or sibling);
Any time (Yes or No).