Table 2.

Cumulative Incidence of AIDS-defining Cancers, and Non-AIDS-defining Cancers Among People with AIDS in the United States, 1980–2006 (N=472,378)

Occurrence of outcome as a first event	Total number of events, by calendar period of AIDS onset			Five-year cumulative incidence (95% confidence interval), by calendar period of AIDS onset
	1980–1989	1990–1995	1996–2006	1980–1989	1990–1995a	1996–2006b
Death	61587	128148	41010	70 (69,70)	55 (54,55)	22 (21,22)
AIDS-defining cancer	15728	23603	7570	18 (18,19)	11 (11,11)	4.2 (4.1,4.3)
Kaposi sarcoma	12196	14597	3277	14.3 (14.1,14.6)	6.7 (6.6,6.8)	1.8 (1.8,1.9)
Non-Hodgkin lymphoma	3463	8690	4011	3.9 (3.8,4.0)	3.8 (3.7,3.9)	2.2 (2.2,2.3)
Cervical cancerc	69	316	282	0.63 (0.50,0.77)	0.73 (0.70,0.82)	0.64 (0.57,0.71)
Non-AIDS-defining cancer	1056	4348	2911	1.1 (1.0,1.1)	1.5 (1.5,1.6)	1.5 (1.4,1.5)
Anal cancer	29	328	196	0.02 (0.01,0.03)	0.07 (0.06,0.08)	0.09 (0.08,0.11)
Hodgkin lymphoma	78	425	359	0.09 (0.07,0.11)	0.15 (0.14,0.17)	0.19 (0.17,0.21)
Liver cancer	22	147	121	0.02 (0.01,0.03)	0.04 (0.03,0.05)	0.06 (0.05,0.07)
Lung cancer	150	915	633	0.14 (0.11,0.16)	0.32 (0.29,0.34)	0.33 (0.30,0.36)

Number of events corresponds to all events over the entire period of follow-up.

Cumulative incidence was calculated using competing risk methods at 60-months of follow-up, expressed as a percentage (%) of people with the specified outcome.

^aCumulative incidence estimates during 1990–1995 were compared to those during 1980–1989 via a 2-sided t-test. Bolded values indicate a significant difference at P<0.05.

^bCumulative incidence estimates during 1990–1995 were compared to those during 1996–2006 via a 2-sided t-test. Bolded values indicate a significant difference at P<0.05.

^cAnalyses were restricted to women.