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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Nat Rev Neurosci. 2010 Apr 14;11(5):301–315. doi: 10.1038/nrn2834

Table 1.

Summary of GIRK knockout mice

GIRK
knockout		 Phenotype Generator
Agonist-evoked GIRK current Behavioral
Brain Heart
VTA SNc CA1 LC Spinal
cord L
II		 Cereb
ellum		 Atrium
GIRK1−/− nc 26 nc 28 ↓ 28 ↓ 31 ↓ 172 • Reduced score in anxiety behavior testing 33 172
GIRK2−/− ↓ 26 ↓ 28 ↓ 27,28 ↓29,30 ↓ 31 ↓ 32

  • Reduced anxiety with signs of hyperactivity33,173

  • Gender difference in latency for tail withdrawal to radiant heat abolished 137,138

  • Reduced cocaine self administration 35

  • Reduced conditioned taste aversion158

  • Spontaneous convulsions and propensity for generalized seizures 145,174

 145
GIRK3−/− ↓ 26 nc 28 nc 28 nc 29
↓ 30 		nc 31

  • Decreased morphine and clonidine analgesia 137

  • Less severe withdrawal from sedatives 34

  • Reduced cocaine self administration 35

 29
GIRK2−/−
GIRK3−/− 		↓ 26 ↓ 28 ↓ 29,30

  • Attenuation of morphine withdrawal 30

  • Propensity for spontaneous and lethal seizures between 2 and 8 months of age 29

  • Increased cocaine self-administration 35

 29
GIRK4−/− ↓ 175 • Impaired performance in the Morris water maze 10 175