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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Horm Behav. 2009 Oct 14;58(1):57–71. doi: 10.1016/j.yhbeh.2009.10.003

Figure 4. Plasma Nicotine Levels After Smoking Three Low- or High-Nicotine Cigarettes.

Figure 4

Plasma nicotine levels after smoking a high-nicotine cigarette (filled circles) and a low-nicotine cigarette (open circles) are shown on the left ordinates. Time (min) is shown on the abscissae. Points above baseline were collected 10 min before smoking the first cigarette began at time 0. A vertical line and an arrow indicate each 4-min cigarette-smoking period. Each data point is the average (± S.E.M.) of 12 men. Statistical analyses indicated significant changes in plasma nicotine levels from baseline in both low- (df=25, F=2.4, P=0.04) and high- (df=25, F=21.1, P<0.0001) nicotine cigarette groups. Significant changes from the pre-smoking baseline are indicated by asterisks (*) (P=0.05 – < 0.0001). Daggers (†) indicate points at which plasma nicotine levels after smoking a low-nicotine cigarette differed from plasma nicotine levels after smoking a high-nicotine cigarette (df=1, F=4.2 – 43.5, P=0.05 – <0.0001). Reprinted with permission from Mendelson, J.H., Goletiani, N.V., Sholar, M.B., Siegel, A.J. and Mello, N.K.: Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men. Neuropsychopharmacology 33:749–760, 2008.