Table 1.

Characteristics of the hierarchical clustering-generated groups

Cluster	A	B	p*
N	7	5
Patient ID numbers	11, 17, 19, 20, 27, 31, 32	2, 8, 15, 16, 42
Maternal age (years)	28 (21–33)	34 (22–35)	0.570
Maternal BMI	30 (23–32)	29 (24–33)	0.915
Parity	0 (0–2)	1 (0.5–1.5)	0.544
Folic acid supplementation (Yes/No)	5/7 (71%)	3/5 (60%)	0.679**
Serum folate (ng/mL)	15.4 (11.4–16.2)	20.0 (13.7–20.0)	0.186
Plasma homocysteine (µmol/L)	13.1 (8.8–13.1)	7.5 (6.7–10.3)	0.038
LINE-1 methylation (%)	69.2 (68.5–73.2)	74.7 (72.9–77.4)	0.028
Birth weight centile (%)	22.4 (3.4–41.3)	57.7 (52.2–92.4)	0.019

Values are expressed as median, with inter-quartile ranges in parentheses, with the exception of folic acid supplementation (expressed as proportion of subjects on supplementation at ≥400 µg/day).

^*p value calculated using Mann-Whitney U test unless otherwise stated.

^**p value calculated from Chi-squared test.