Table 2.

CpG sites demonstrating significant correlations with plasma homocysteine concentration, birth weight centile and mean LINE-1 methylation level

	Gene symbol	Accession no.	Target ID	CpG ISLAND (yes/no)	chromosome	Mean beta value (range)	Mean LINE-1 methylation (r)	Plasma homocysteine (r)	Birth weight centile (r)
A	EIF2C3	NM_024852.2	cg24196046	Y	1p34.3	0.25 (0.14–0.34)	−0.652	0.622	−0.822
	ZBTB11	NM_014415.1	cg10218646	Y	3q12.3	0.22 (0.06–0.44)	−0.772	0.686	−0.751
	BDH2	NM_020139.3	cg02214188	N	4q24	0.50 (0.399–0.58)	−0.580	0.620	−0.711
	ZNF187	NM_152736.3	cg26450541	Y	6p21.31	0.15 (0.07–0.24)	−0.619	0.602	−0.674
	RUNX1T1	NM_004349.2	cg19007731	N	8q22	0.40 (0.33–0.46)	−0.683	0.657	−-0.763
	C9orf64	NM_032307.2	cg02654291	Y	9q22.1	0.42 (0.31–0.51)	−0.590	0.673	−0.605
	PDE2A	NM_002599.1	cg23792978	N	11q13.1–14.1	0.29 (0.22–0.37)	−0.639	0.816	−0.636
	MGC33486	NM_153266.2	cg05322222	Y	11q13.2	0.23 (0.18–0.28)	−0.748	0.735	−0.616
	AMN	NM_030943.1	cg09616556	N	14q32.32	0.68 (0.57–0.79)	−0.630	0.709	−0.637
	ZPBP2	NM_198844.1	cg14914852	Y	17q12	0.69 (0.59–0.80)	−0.687	0.689	−0.776
	FBN3	NM_032447.3	cg14156381	N	19p13.2	0.51 (0.46–0.56)	−0.668	0.731	−0.746
	PVRL2	NM_002856.1	cg08054038	Y	19q13.2	0.40 (0.35–0.51)	−0.612	0.615	−0.676
B	ATP5F1	NM_001688.3	cg12955127	N	1p13.2	0.61 (0.55–0.68)	0.707	−0.732	0.592
	CYP26C1	NM_183374.2	cg20322977	Y	10q23.3	0.26 (0.22–0.38)	0.648	−0.733	0.748
	FSTL3	NM_005860.1	cg10503234	Y	19p13	0.36 (0.27–0.45)	0.750	−0.664	0.609
	MDS032	NM_018467.2	cg01252496	Y	19p13.11	0.49 (0.42–0.58)	0.585	−0.639	0.674
	BMX	NM_001721.4	cg22745747	Y	Xp22.2	0.63 (0.56–0.69)	0.631	−0.813	0.760

Part A (12 CpG sites) shows those inversely correlated with LINE-1 methylation/birth weight centile and directly with plasma homocysteine. Part B (5 CpG sites) shows those directly correlated with LINE-1 methylation/birth weight centile and inversely with plasma homocysteine.