Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Clin Geriatr Med. 2011 Feb;27(1):27–37. doi: 10.1016/j.cger.2010.08.006

Table 1.

Cellular and systemic response regulation by key transcription factors.

Transcription Factor
Response p53 Rb NF-κB FOXO
 Apoptosis ↑ [72] ↓ [73] ↓ [74] ↑ [75]
 Senescence ↑ [76] ↑ [45] ↑ [77] ↑ [78]
 Repair/autophagy ↓ [79] ↓ [80] ↓ [81] ↑ [82]
 Inflammation ↓ [83] ↓ [84] ↑ [85] ↓ [86]

The induction (↑) or repression (↓) of cellular and systemic responses by key transcription factors and the references supporting that assessment are given in parenthesis.