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Entropy Reduction of Activity Data with siRNA Classification Methods
| Dataset | Classification | Entropy | Entropy Reduction |
|---|---|---|---|
| Shabalina [30] | None | 3.32 | N/A |
| Terminal Nucleotide | 2.92 | 0.40 | |
| ΔΔG (1 nn) | 3.07 | 0.25 | |
| ΔΔG (2 nn) | 3.09 | 0.23 | |
| ΔΔG (3 nn) | 3.10 | 0.22 | |
| ΔΔG (4 nn) | 3.16 | 0.16 | |
| Novartis [31] | None | 3.32 | N/A |
| Terminal Nucleotide | 3.07 | 0.25 | |
| ΔΔG (1 nn) | 3.16 | 0.16 | |
| ΔΔG (2 nn) | 3.19 | 0.13 | |
| ΔΔG (3 nn) | 3.23 | 0.09 | |
| ΔΔG (4 nn) | 3.23 | 0.09 |
All ΔΔG calculations include an AU end penalty [63]. nn - nearest neighbor.
