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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Immunol. 2010 Dec 1;32(1):6–11. doi: 10.1016/j.it.2010.10.004

Figure 2. Conformational MHC class II variations and differential MHC class II peptidome on the surface of immature and mature DCs.

Figure 2

a) Immature DCs and non-activated APCs are particularly competent for surface MHC II loading compared with mature or activated APCs [42]. Becasue DO expression is higher on immature DCs and non-activated APC the inhibitory function of DO on DM catalytic activity, favors a broader, less stable and more easily exchanged MHC II/peptide repertoire [50,51]. b) Immature DCs (left) present a broader peptide repertoire as well as a less stable and empty (peptide non-receptive and receptive) MHC class II complexes. Mature DCs express a more focused peptidome and more stable MHC class II complexes [40–47, 53–56]. c) Schematic showing surface peptide loading events on MHC class II molecules in immature DCs. Five possibleMHC class II molecule conformations are shown: peptide non-receptive (P1 pocket collapsed), peptide-receptive (P1 pocket open or filled) and peptide-loaded (binding groove occupied by the loaded peptide).