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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: J Biol Chem. 2005 Dec 28;281(12):8016–8023. doi: 10.1074/jbc.M511599200

FIGURE 3. Histopathology of Fbn1 null aortas.

FIGURE 3

A, immunostaining with anti-Von Willebrand factor antibody of cross-sections of aortas from a randomly sacrificed (P14) and a dead (pm) Fbn1 null (−/−) mouse showing detachment of the endothelial lining (arrows). Control samples were from sex- and age-matched wild-type (+/+) littermates. The signal was pseudocolored using Adobe Photoshop software to best appreciate the immunostaining. B, Weigert staining of aortic tissues in segments other than the focal lesions of Fbn1 null mice (−/−) and in comparable regions of the wild-type (+/+) aorta. Arrows indicate discontinuities in elastic fibers. Scale bar, 100 μm in both panels.