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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Arch Neurol. 2009 Mar;66(3):352–361. doi: 10.1001/archneurol.2008.588

Figure 5.

Figure 5

Peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α) expression inversely correlates with forkheadlike transcription factor 1 (FoxO3a) expression in the Alzheimer disease (AD) brain as a function of progression of clinical dementia. A, Forkheadlike transcription factor 1 messenger RNA (mRNA) content in hippocampal formation (quantified by real-time reverse transcriptase–polymerase chain reaction and normalized by neuron-specific enolase [NSE]) as a function of Clinical Dementia Rating (CDR). B, Western blot confirmation of increased FoxO3a protein contents in the hippocampal formation of AD cases. *P<.01, †P<.003, and ‡P<.05 vs control group by t test. C-E, Scatterplot analysis of FoxO3a protein expression (n=13) as a function of PGC-1α expression (C), Consortium to Establish a Registry for Alzheimer's Disease (CERAD) 4-point scale (n=3, 4, 2, and 3 for CERAD scores of 0, 1, 3, and 5, respectively) for AD (D), or for content of β-amyloid (Aβ)x-42 (n=12) in the brain of AD cases (E). Straight line represents best linear regression fit.