Table 1.
Summary of parameters analyzed after intratracheal (IT) and two inhalation (2x IH) challenges with Aspergillus fumigatus in antigen-sensitized C57BL/6 mice.
| Analyzed parameter | IT | 2x IH |
|---|---|---|
| Macrophage recruitment | +(+) | + |
| Neutrophil recruitment | +++ | + |
| Eosinophil recruitment | + | ++ |
| Lymphocyte recruitment | + | +++ |
| Serum IgE | + | +++ |
| BAL fluid IgE | + | +++ |
| Serum IgG2a | + | (+) |
| BAL fluid IgG2a | +++ | + |
| Peribronchovascular inflammation | ++ | +++ |
| Goblet cell metaplasia | ++ | +++ |
| Subepithelial fibrosis | + | +++ |
| Smooth muscle cell hyperplasia | (+) | +++ |
Relative increases in the modulation of these parameters are represented with + symbols as compared to naïve controls. Parentheses are indicative of incremental changes.