Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Immunol. 2010 Nov 8;32(1):19–25. doi: 10.1016/j.it.2010.10.002

Figure 3. Schematics of possible signaling pathways involved in MDSC activation.

Figure 3

Bacterial and viral products, as well as cytokines released by activated T cells or myeloid cells induce activation of Stat1, Stat6 and TLR signaling. Stat1 and Stat6 act directly and TLR signaling via MyD88 and NF-κB to up-regulate proteins directly involved in the immune suppressive activity of MDSC.