Table 3.
Haplotype Analysis of BHMT in Adult Liver Samples
| (A) Overall haplotype summary. | ||
|---|---|---|
| Phenotype | Global test of haplotype association1 | Test of largest haplotype effect2 |
| Protein level | 0.023 | 0.020 |
| Enzyme activity | 0.0016 | 0.0186 |
| (B) Haplotype analysis for BHMT enzyme activity. | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs57906668 | rs682985 | rs41272270 | rs16876512 | rs542852 | rs6875201 | rs16876527 | rs506500 | rs567754 | rs59866108 | rs3733890 | rs585800 | Hap-Freq | Hap-Score | p-value |
| A | A | A | A | G | G | A | G | G | G | A | A | 0.03084 | 3.25699 | 0.00082 |
| A | A | A | A | G | G | A | A | G | G | T | A | 0.02281 | 2.66864 | 0.00658 |
| A | A | G | G | G | A | A | G | A | G | T | A | 0.27859 | −2.36256 | 0.01974 |
| A | A | G | G | G | A | A | G | G | G | A | A | 0.0379 | −2.07265 | 0.03834 |
| A | A | G | G | A | A | A | G | G | G | A | A | 0.02088 | −1.71641 | 0.081 |
| A | A | A | A | G | G | A | A | G | G | T | T | 0.01062 | 1.64793 | 0.11112 |
| A | A | A | A | G | G | A | G | A | G | T | A | 0.02834 | 1.61042 | 0.11194 |
| A | A | G | G | G | A | A | A | G | G | T | T | 0.11589 | −1.42933 | 0.15399 |
| A | A | G | G | G | A | A | G | G | G | T | A | 0.01879 | −1.32689 | 0.1837 |
| A | G | G | G | G | A | G | G | G | G | T | A | 0.02073 | 0.76239 | 0.45076 |
| G | G | G | G | A | A | A | G | G | G | A | A | 0.1781 | 0.59642 | 0.56219 |
| A | G | G | G | G | A | A | A | G | G | T | A | 0.01282 | −0.41139 | 0.68452 |
| A | G | G | G | A | A | G | A | G | G | T | T | 0.01534 | 0.37383 | 0.71073 |
| A | G | G | G | A | A | A | A | G | G | T | T | 0.13483 | 0.17011 | 0.86852 |
| (C) Haplotype analysis for BHMT protein level. | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs57906668 | rs682985 | rs41272270 | rs16876512 | rs542852 | rs6875201 | rs16876527 | rs506500 | rs567754 | rs59866108 | rs3733890 | rs585800 | Hap-Freq | Hap-Score | p-value |
| A | A | A | A | G | G | A | G | G | G | A | A | 0.03084 | 3.32181 | < 0.001 |
| A | A | G | G | G | A | A | G | A | G | T | A | 0.27859 | −2.55085 | 0.012 |
| A | A | A | A | G | G | A | A | G | G | T | T | 0.01062 | 2.44239 | 0.016 |
| A | A | A | A | G | G | A | G | A | G | T | A | 0.02834 | 1.99501 | 0.053 |
| A | A | G | G | G | A | A | G | G | G | T | A | 0.01879 | −1.32619 | 0.18 |
| A | A | G | G | G | A | A | A | G | G | T | T | 0.11589 | −1.23016 | 0.194 |
| G | G | G | G | A | A | A | G | G | G | A | A | 0.1781 | 1.03721 | 0.315 |
| A | A | G | G | G | A | A | G | G | G | A | A | 0.0379 | −0.98676 | 0.318 |
| A | G | G | G | A | A | G | A | G | G | T | T | 0.01534 | 0.70565 | 0.474 |
| A | G | G | G | A | A | A | A | G | G | T | T | 0.13483 | 0.54181 | 0.566 |
| A | G | G | G | G | A | G | G | G | G | T | A | 0.02073 | −0.4716 | 0.603 |
| A | A | G | G | A | A | A | G | G | G | A | A | 0.02088 | −0.45823 | 0.637 |
| A | A | A | A | G | G | A | A | G | G | T | A | 0.02281 | 0.47948 | 0.647 |
| A | G | G | G | G | A | A | A | G | G | T | A | 0.01282 | 0.15124 | 0.873 |
1
Simulation based p values for the global test of haplotype association using a score test.
2
Simulation based p values for maximum score statistic.