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Extracellular TGFBIp production by HCECs is reduced after transfection with siRNAs targeting TGFBI mRNA. Each of the seven commercially available siRNAs (at 30 nM concentration) reduced the amount of extracellular TGFBIp compared with HCECs that were exposed to the transfection reagent but not to an siRNA (no siRNA control). Additionally, the inhibition of TGFBIp production by several of the siRNAs was much greater than that observed with the scrambled siRNA control.
