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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Trends Cardiovasc Med. 2010 May;20(4):120–124. doi: 10.1016/j.tcm.2010.10.002

Figure 1.

Figure 1

Role of Ca2+ and Ca2+ channels in regulation of Plg-Rs. Stimulation of leukocytes, including stimuli that induce differentiation of monocytes into macrophages mobilize Ca2+ entry into cells, either through existing channels or by triggering synthesis of Ca2+ channels, particularly of the L-type Ca2+ channel variety. The pathways involved lead to enhanced expression of both tailed and tailless Plg-Rs at cell surface. Plg binding and activation on leukocytes facilitates leukocyte migration during an inflammatory response. Inhibitors of Ca2+ channels can inhibit the upregulation of Plg-Rs and suppress inflammation.