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RING domain amino acids with protein-protein interaction potential. The 8 cysteines shown in red are predicted to coordinate the two Zn++ ions, stabilizing the RING finger structure. They are indispensable for SPE-42 function except for C681, loss of which can be partially compensated for by C678 (see Tables 1 and 2). Amino acids colored blue are predicted to be on the protein surface and within 5Å of a theoretical binding partner by the model shown in Fig. 2B.
