Table 1.

Corneal Defects in TSP1^−/−, TLR2^−/−, and CD36^−/− Mice

Mouse Strain	Severity of Defect*
	Age (mo)	No Defect	Mild Defect	Severe Defect
CD36−/− knockout*	2–6	31	2	1
	8–11	22	11	3
	16	0	12	8†
TSP1−/− knockout‡	2–6	40	0	0
	8–11	43	0	0
TLR2−/− knockout§	19–25	8	0	0

^*Data presented in Figure 1 and summarized here, n = 90.

^†Frequency of severe defects was compared using Fisher's exact test between (1) CD36^−/− mice 16 months old with TLR2^−/− mice 19–25 years old (P = 6.4 × 10⁻⁷), and (2) CD36^−/− mice 8–11 months old with TSP1^−/− mice 8–11 months old (P = 3.1 × 10⁻⁶).

^‡n = 83.

^§n = 8.