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. 2011 Mar 10;7(3):e1001102. doi: 10.1371/journal.pcbi.1001102

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Linaro et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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When weakly depolarising DC currents (A, ) are applied to both the microscopic (black sample trace) and the effective models (red sample trace), the increase in channel noise variances (see Fig. 2C,F) induces a highly irregular spontaneous emission of action potentials, with qualitatively very similar properties. In these simulations, both length and diameter of the neuron are set to , and the single channel conductance for both sodium and potassium channels is . Panels B,C show respectively the CV of the ISI distribution and the mean firing rate as a function of cell diameter: results are reported for the microscopic, effective and Fox's models (black, red and blue traces, respectively). The results of panels B,C refer to spontaneous activity (i.e., no injected current) with neuron length held fixed at the value .

Inline graphic — When weakly depolarising DC currents (A, ) are applied to both the microscopic (black sample trace) and the effective models (red sample trace), the increase in channel noise variances (see Fig. 2C,F) induces a highly irregular spontaneous emission of action potentials, with qualitatively very similar properties. In these simulations, both length and diameter of the neuron are set to , and the single channel conductance for both sodium and potassium channels is . Panels B,C show respectively the CV of the ISI distribution and the mean firing rate as a function of cell diameter: results are reported for the microscopic, effective and Fox's models (black, red and blue traces, respectively). The results of panels B,C refer to spontaneous activity (i.e., no injected current) with neuron length held fixed at the value .