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. 2011 Mar 10;7(3):e1001102. doi: 10.1371/journal.pcbi.1001102

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Linaro et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panels A, B and C display the firing efficacy, the average latency and the jitter of the evoked responses, respectively, after the application of a monophasic stimulus of duration repeated for 10000 trials. Black and red traces and dots result from the simulations of the exact kinetic schemes and from our diffusion approximation, and in blue we indicate the results from the simulation of the Langevin-approximation introduced by Fox. Panel D shows the distribution of spike occurrence times, evoked by a biphasic stimulus over 10000 trials: the duration and amplitude of the preconditioning part are and , respectively, the duration and amplitude of the second part are and . In all panels, the neuron is simulated as a single cylindrical compartment of length and diameter equal to and single channel conductances equal to , for both sodium and potassium channels. The integration time step was set to .

Inline graphic — Panels A, B and C display the firing efficacy, the average latency and the jitter of the evoked responses, respectively, after the application of a monophasic stimulus of duration repeated for 10000 trials. Black and red traces and dots result from the simulations of the exact kinetic schemes and from our diffusion approximation, and in blue we indicate the results from the simulation of the Langevin-approximation introduced by Fox. Panel D shows the distribution of spike occurrence times, evoked by a biphasic stimulus over 10000 trials: the duration and amplitude of the preconditioning part are and , respectively, the duration and amplitude of the second part are and . In all panels, the neuron is simulated as a single cylindrical compartment of length and diameter equal to and single channel conductances equal to , for both sodium and potassium channels. The integration time step was set to .