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. 2011 Mar 10;7(3):e1001331. doi: 10.1371/journal.pgen.1001331

Table 1. Co-expression analysis of all datasets is consistent with the PAM unsupervised clustering.

BIOLOGICAL PROCESSES MODULE N° −LOG(P-value)
Cell cycle Module 1 18.39935
Synaptogenesis/TNI Module 3 14.01381
Translation/Trancription Module 4 11.70093
Inflammation/Muscle contraction/Ossification Module 2 5.817329
DNA damage/Proteolysis/Cell cycle Module 8 5.17276
Translation in Mitocondria Module 12 4.837137
Cell cycle/Apoptosis/Synaptogenesis Module 9 4.734231
Inflammation/Muscle contraction Module 6 4.009217
Autophagy Module 14 3.871601
Immune phagocytosis/Cytoskeleton/Cell adhesion Module 5 3.827582
Axonal guidance/TNI/Cell adhesion Module 11 3.631598
Inflammation/Translation/Signal transduction Module 19 3.383735
Transcription/Apoptosis Module 21 3.31721
Neurogenesis in general/development Module 22 3.209552

Metacore pathway analysis of the 25 modules (WGCNA) defined 14 modules with top enrichment values (FDR<0.05). Consistent with the PAM analysis, cell cycle, synaptogenesis and translation/transcription genes are highly co-expressed during brain development.

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