Table 1. Co-expression analysis of all datasets is consistent with the PAM unsupervised clustering.
BIOLOGICAL PROCESSES | MODULE N° | −LOG(P-value) |
Cell cycle | Module 1 | 18.39935 |
Synaptogenesis/TNI | Module 3 | 14.01381 |
Translation/Trancription | Module 4 | 11.70093 |
Inflammation/Muscle contraction/Ossification | Module 2 | 5.817329 |
DNA damage/Proteolysis/Cell cycle | Module 8 | 5.17276 |
Translation in Mitocondria | Module 12 | 4.837137 |
Cell cycle/Apoptosis/Synaptogenesis | Module 9 | 4.734231 |
Inflammation/Muscle contraction | Module 6 | 4.009217 |
Autophagy | Module 14 | 3.871601 |
Immune phagocytosis/Cytoskeleton/Cell adhesion | Module 5 | 3.827582 |
Axonal guidance/TNI/Cell adhesion | Module 11 | 3.631598 |
Inflammation/Translation/Signal transduction | Module 19 | 3.383735 |
Transcription/Apoptosis | Module 21 | 3.31721 |
Neurogenesis in general/development | Module 22 | 3.209552 |
Metacore pathway analysis of the 25 modules (WGCNA) defined 14 modules with top enrichment values (FDR<0.05). Consistent with the PAM analysis, cell cycle, synaptogenesis and translation/transcription genes are highly co-expressed during brain development.