Table V. Ispinesib plasma pharmacokinetic parameters by dose level.

Dose level mg/m2/dose	Patient	Cmax (ng/mL)	AUClast (hr*ng/mL)	AUCINF (hr*ng/mL)	t1/2 (hr)	Clearance (L/hr/m2)	Vss (L/m2)
5	737478**	86	945	1662	44	3.0	177	*
	757897	145	908	938	9	5.3	61
7	744676	181	1319	1449	14	4.8	84	*
	758892**	244	3716	5733	32	1.2	51
	767535	1900	4090	4596	18	1.5	24	*
	769075	75	851	970	15	7.2	145
9	763246	1880	4814	5243	16	1.7	23	*
	763770	281	2506	3811	33	2.4	102
	769877	149	1526	1865	19	4.8	118
12	764399	149	819	890	13	13.5	193
	771172**	204	732	1690	8	7.1	83

^*Protocol deviation with samples obtained from same venous access site as drug administration; concentrations obtained may be overestimates;

^*AUC extrapolated values for these patients were >30% (fewer data points were available for these patients).