Figure 1.

Cell culture screening using FDA approved drugs which were identified from genomic profiling and IHC data showed inhibition of cell proliferation of patient's acinar cell pancreatic carcinoma cell line. Drugs were selected based upon gene array (Incyte) and immunohistochemistry data that identified druggable molecular targets present in the tumor known to be a molecular target for each drug. Cells established from a liver biopsy of the patient's tumor tissue were plated at 2 x 10⁴ cells/ml/well on day 0 and treated with the indicated drugs and concentrations on day 1. Media was changed every 48 hrs along with addition of new drugs. On day 6, cells were photographed at 20x magnification and counted using a Coulter Counter. Data are expressed as the mean and S.D. * indicates statistical difference from Control (P< 0.05).