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. Author manuscript; available in PMC: 2012 Jan 12.
Published in final edited form as: Structure. 2011 Jan 12;19(1):128–140. doi: 10.1016/j.str.2010.10.009

Figure 6. Models of Dark, Apaf-1 and CED-4 apoptosomes.

Figure 6

A. The platform region of the octagonal Dark apoptosome is shown as a molecular ribbon diagram, viewed along the 8-fold axis in a top view.

B. The Dark apoptosome is shown in a top view with the CARDs, to highlight the formation of a CARD crown on the central hub.

C. The heptameric Apaf-1 apoptosome is shown in a top view with bound cytochrome c (although the position of the latter is still being refined; Yuan et al., 2010).

D. (top left) A top view is shown of the octameric CED-4 apoptosome, with CARDs omitted to provide an unobstructed view of the central hub. (bottom right) The CED-4 apoptosome is shown with the double-layered CARD disk, which has 4-fold symmetry (Qi et al., 2010).

See also Figure S8.