Table II.
GO biological processes over-represented in both E. coli and S. cerevisiae UV-toxicity modulating proteins, as identified by Functionome mapping
| GO Functional Category | E. coli | Saccharomyces cerevisiae | Combined | |||
|---|---|---|---|---|---|---|
| # UV Sensitive | Genes | # UV Sensitive | Genes | Total UV Sensitive | P- Value | |
| Response to DNA damage stimulus | 16 | cho, mfd, rada, reca, recb, recc, recf, reco, recr, ruva, ruvc, umuc, uvra, uvrb, uvrc, uvrd, yebg | 51 | RAD16, RAD18, SLX5, DUN1, NUP84, RAD57, HPR1, RAD9, RAD34, XRS2, RAD30, RAD23, SLX8, RAD4, RAD24, RAD6, RPB9, MMS2, RAD54, RAD2, WSS1, MET18, REV7, CTK2, RPB4, RAD7, GRR1, MGM101, DEF1, CTK1, RAD5, BUR2, TOP3, MEC3, BDF1, RAD33, RAD52, RAD10, CTK3, CTF18, NPL6, SGS1, RAD14, EAF7, CKB2, REV1, RAD17, RAD1, PHO85, REV3, DDC1 | 67 | 1.00E-04 |
| DNA repair | 17 | cho, mfd, radA, recA, recB, recC, recF, recO, recR, ruvA, ruvC, umuC, uvrA, uvrB, uvrC, uvrD, yebG | 42 | RAD16, RAD18, SLX5, SIT4, DUN1, RAD57, RAD9, RAD34, XRS2, RAD30, RAD23, SLX8, RAD4, RAD24, RAD6, RPB9, RAD54, RAD2, WSS1, MET18, REV7, SPT10, RPB4, RAD7, MGM101, IXR1, RAD5, TOP3, MEC3, BDF1, RAD33, RAD52, RAD10, CTF18, SGS1, RAD14, EAF7, REV1, RAD17, RAD1, REV3, DDC1 | 59 | 1.00E-04 |
| Nucleotide-excision repair | 3 | uvrA, uvrB, uvrC, cho | 10 | RAD9, RAD34, RAD23, RAD4, RAD24, RAD2, SNF6, MET18, RAD33, RAD14 | 13 | 1.00E-04 |
| DNA replication | 9 | dnaG, dnaK, dnaT, holC, holD, priA, priB, recF, uvrD | 14 | RAD9, RAD30, RNR1, RAD24, RNR4, WSS1, TOP3, RAD52, CTF18, SGS1, MIP1, REV1, RAD17, REV3 | 23 | 1.00E-04 |
| DNA metabolic process | 3 | dnaG, recA, recR | 4 | RAD57, TOP3, MEC3, RAD1 | 7 | 1.24E-02 |
| tRNA aminoacylation for protein translation | 2 | poxA, yadB | 5 | SLM5, ARC1, DIA4, MSK1, MSE1 | 7 | 1.24E-02 |
| Aerobic respiration | 2 | nuoF, nuoH | 7 | YDR115W, QCR7, QCR6, DIA4, OAR1, MCT1, PET20 | 9 | 1.64E-02 |
| Translation | 7 | poxA, prfB, rpmF, rpsO, rpsT, rpsU, yadB | 26 | RPS8A, FES1, SLM5, MTF2, RPL31A, RPL35B, YDR115W, CBS2, MRPL7, MRP20, RPL12B, RML2, RPL7A, RPL1B, RPS0A, DIA4, MTG2, CTK1, MEF1, RPS17A, RPL20A, MSK1, MRPS12, RSM19, IFM1, MSE1 | 33 | 2.78E-02 |
| Regulation of translation | 2 | ihfA, ihfB | 13 | TPD3, RPS8A, FES1, NAT1, MSS116, CBS2, RPL12B, PUF6, PET122, RPL7A, RPS0A, RPS17A, RPL20A | 15 | 4.55E-02 |
| DNA recombination | 8 | ihfA, ihfB, intA, recA, recO, recR, ruvA, ruvC | 5 | HPR1, ERG28, THP2, RAD52, SGS1 | 13 | 5.70E-02 |