Table IV.
GO biological processes over-represented in the 310 UV-toxicity modulating proteins from S. pombe
| Functional Process | Total Tested | # UV Sensitive | Genes | P-value |
|---|---|---|---|---|
| Protein amino acid acetylation | 5 | 3 | ATS1, SPBC1271.07C, SPBC418.02 | 1.59E-04 |
| Ribosome biogenesis | 50 | 11 | GAR2, RPL501, RPS1102, RPS1602, RPS1801, RPS902, RRP16, SPBC776.17, RMT3, SPAC589.10C, TCG1 | 6.87E-04 |
| RNA processing | 4 | 2 | PET127, REX3 | 2.56E-03 |
| Glycerophospholipid biosynthetic process | 3 | 2 | SPAC1851.02, SPBC16A3.10 | 2.56E-03 |
| mRNA polyadenylation | 4 | 2 | SPBC21B10.03C, CTF1 | 3.47E-03 |
| Protein homooligomerization | 5 | 2 | RAD22, RTI1 | 4.66E-03 |
| Response to arsenic | 6 | 2 | MCS4, STY1 | 4.66E-03 |
| Chromosome segregation | 23 | 5 | AGO1, ALP14, CID12, SIR2, SPCC576.12C | 8.20E-03 |
| Response to hydrogen peroxide | 7 | 2 | MCS4, STY1 | 1.39E-02 |
| Cellular iron ion homeostasis | 10 | 3 | STR1, STR3, CUF1 | 2.28E-02 |
| Copper ion transport | 4 | 2 | CTR5, SCO1 | 2.28E-02 |
| Respiratory chain complex iv assembly | 5 | 2 | OXA102, SCO1 | 2.87E-02 |
| DNA recombination* | 6 | 2 | PNU1, SSB3 | 4.46E-02 |
| Response to DNA damage stimulus* | 27 | 5 | NSE5, RAD8, RHP55, RTT109, SWI3 | 6.68E-02 |
| Nucleotide-excision repair* | 10 | 2 | RAD8, UVE1 | 8.08E-02 |
| Intracellular protein transport | 67 | 10 | APL1, APM1, SPAC4F10.16C, SPAC644.13C, VPS1302, VPS3, VPS5, FSV1, GOS1, SPAC17A5.08 | 8.08E-02 |
| Regulation of catalytic activity | 59 | 9 | PAR1, RGA9, TSF1, ZDS1, SPAC1F3.03, SPAC227.06, SPAC644.13C, SPCC306.02C, VPS3 | 9.68E-02 |
| Translation* | 116 | 14 | RPL1801, RPL2002, RPL2301, RPL2701, RPL702, RPL803, RPS1102, RPS1501, SPAC3A12.13C, RPL501, RPS1602, RPS1801, RPS902, SPBC25B2.01 | 9.68E-02 |
*
indicates a biological process that was also identified in our Functionome analysis