Figure 5.
A, NOGA endocardial mapping of pig left ventricle 16 days after MI with 12 injections (black points) of LV-RL-RFP-tTK-MSC at the border zone of anterior wall MI. B, PET image of a pig 30 hours after injection of LV-RL-RFP-tTK-MSC demonstrates diffuse high tracer activity in the myocardium, corresponding with the 12 injection sites of the transfected cells. The emission and transmission slices are represented by hot color bar and grayscale with standard uptake values. C, No uptake is detected in the control animal. D, PET images seven days after injection of LV-RL-RFP-tTK-MSCs with decreased but still detectable scattered tracer activity in the myocardium in the MSC-treated animal, and in the surrounding tissues indicating wandering of the living cells probably through the lymphatic routes. E, No tracer accumulation in the control pig at 23 days after MI.