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. 2011 Feb 17;108(10):4006–4011. doi: 10.1073/pnas.1019025108

Fig. 1.

Fig. 1.

GATA4 mutations cause endocardial cushion defects. (A) Family A pedigree with cosegregation of GATA4 G303E mutation (+) with congenital heart disease (Left). Note that five mutation carriers had endocardial cushion defects (Right). (B) Family B pedigree with cosegregation of GATA4 G296S mutation (+) with congenital heart disease (Left). Note that six mutation carriers had endocardial cushion defects (Right). Electrophysiologic (EP) status and events of mutation carriers are indicated: AF, atrial fibrillation; EAR, ectopic atrial rhythm; LAD, left axis deviation, PM, pacemaker; SCD, sudden cardiac death; SR, sinus rhythm, SVT, supraventricular tachyarrhythmia.