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Endocardial proliferation defect in endocardial-deficient Smad4 embryos. (A and B) Significantly more surface endocardial cell proliferation in wild type (A: 3.24 ± 1.4) than in Tie2:Cre+; Smad4fl/− (B: 1.04 ± 0.7) embryos at E10.5 (P = 1.8 × 10−5). (C–H) Parasagital heart sections from wild-type (C, E, and G) and Tie2:Cre+; Smad4fl/− (D, F, and H) embryos treated with BrdU at E9.5 and stained for BrdU uptake (C–F) or DAPI (G and H) at E10.5.
