Fig. 3.

HDAC inhibition blocks the augmented hypertrophic growth response in α-MHC–Beclin 1 transgenic mice. Cardiac-specific Beclin 1 overexpressing transgenic mice (8–10 wk of age) were subjected to sham or TAC procedures. The animals were then randomized into four groups: sham + veh, sham + TSA (1.0 mg/kg SQ QD), TAC + veh, or TAC + TSA and followed for 3 wk. Heart mass normalized to body mass (HW/BW) increased in both genotypes but significantly more in the Beclin 1 transgenics (A). Representative images of whole hearts and four-chamber sections (B) and mean data (n = 7–11, C) are presented. HDAC inhibition elicited a significantly greater reduction in heart growth in Beclin 1 transgenics relative to WT (D).