Fig. 2.

Evolution of protein abundances and PPIs after several rounds of preequilibration (Fig. S1). Green curves correspond to a functional monomer, the red curve is the average over two proteins forming a stable pair heterodimer (k = 1), and the blue curve corresponds to the average over three date triangle proteins (k = 2). (A) Mean concentration of each protein, C_i. (B) The fraction of protein material that is sequestered in nonfunctional interactions, ns_i. (C) The strength of PPI in the functional complex, P_int, except the first protein that does not form any functional complex. All curves are ensemble averaged over 200 independent simulation runs.