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Aerobic glycolysis and mitophagy in the tumor stromal compartment. PKM2, LDH-B and BNIP3L are all highly expressed in the tumor stromal compartment of human breast cancers that lack the stromal expression of Cav-1. PKM2 and LDH-B are markers of aerobic glycolysis, while BNIP3L is a functional marker of the autophagic destruction of mitochondria (mitophagy). Images were reproduced from references 4, 26 and 27, with permission from the publisher (Landes Bioscience).
