Figure 2.

Effects of DG post-treatment on mitochondrial glutathione status and lipid peroxidation in ISO-challenged rat hearts. (A) Mitochondrial reduced glutathione (GSH) level, glutathione reductase (GR), Se-glutathione peroxidase (GPX) and isocitrate dehydrogenase (ICDH) activities as well as malondialdehyde (MDA) level were measured. (B) The degree of protection against ISO-induced changes in mitochondrial parameters was estimated as described in Methods. Values are means ± SD (n = 6). * Significantly different from animals receiving saline injection without ISO; ^# significantly different from the time-matched ISO-challenged animals without DG post-treatment