Table 2.

Univariable Linear Regression Models of the Relationship of Demographic, Inflammatory, and Other Factors With Plasma esRAGE Levels in Adults, 20–97 Years, in the InCHIANTI Study

Characteristic	β	SE	p
Age (y)	0.001	0.0008	.19
Gender	−0.076	0.030	.003
Education >12 (y)	−0.001	0.003	.63
Body mass index (kg/m2)	−0.021	0.003	<.0001
Mini-Mental State Exam score <24	0.054	0.03	.07
Alcohol intake (gm/d)	−0.0012	0.0007	.12
Current smoker	0.035	0.033	.30
Aspirin use	0.052	0.028	.07
Estimated glomerular filtration rate (mL/min/1.732)	−0.004	0.0007	<.0001
Total plasma polyunsaturated fatty acids (mg/L)	−0.00002	0.00002	.27
Fasting blood glucose (mg/dL)	−0.0004	0.0005	.41
Triglycerides (mg/dL)	−0.0003	0.0002	.05
Total cholesterol (mg/dL)	−0.0004	0.0003	0.23
High-density lipoprotein cholesterol (mg/dL)	−0.0006	0.0009	.50
Low-density lipoprotein cholesterol (mg/dL)	−0.0001	0.0004	.81
Total carotenoids (μmol/L)	0.023	0.019	.22
α-Tocopherol (μmol/L)	0.0007	0.002	.64
Uric acid (mg/dL)	0.008	0.009	.37
Log carboxymethyl-lysine (ng/mL)	0.156	0.044	.0004
Hypertension	−0.043	0.026	.10
Angina	−0.020	0.069	.77
Stroke	−0.009	0.062	.89
Diabetes	−0.014	0.041	.72
Congestive heart failure	0.15	0.063	.02
Peripheral artery disease	0.09	0.060	.13
Cancer	0.004	0.058	.93

Note: esRAGE = endogenous secretory RAGE.