Table 3. Treatment Effects on Brain Response to Painful Stimulation.

Region	X: Y: Z	k	t	pUnc.
Week 1 treatment effects. Interaction effects (baseline to week 1)
Insula–Operc.–HPC	−40 8 14	701	3.46	0.001
	48 −10 −6	761	2.68	0.005
Basal ganglia	−12 8 22	204	2.71	0.004
	12 4 22	395	2.69	0.005
Hypothal. region–Med. PFC	6 −2 −16	355	3.88	<0.0001
Middle temp. gyrus	−66 −36 0	765	3.55	<0.0001
Subg. Preg. ACC	−6 50 −10	5515	3.86	<0.0001
Dorsolat. PFC	−36 22 34	1097	2.78	0.004
	20 34 26	1014	3.03	0.002
Week 8 treatment effects. Interaction effects (baseline to week 8)
Anterior Insula–frontal Op.	−46 20 −2	1039	2.94	0.002
Posterior insula–Temp Op.	−44 −24 −6	281	3.17	0.001
	44 −16 −6	315	2.82	0.003
Hypothal. region–Med. PFC	4 −2 −16	358	3.05	0.002
Middle Temp. gyrus	−60 −42 4	473	3.36	0.001
Subg. Preg. ACC	2 22 −24	1368	3.70	<0.0001
Dorsolat. PFC	−30 48 14	219	2.84	0.003
	34 26 34	1002	3.40	0.001
Inferior pons	2 −38 −36	1717	3.08	0.002
Superior pons	0 −20 −24	1717	2.92	0.002

Abbreviations: k, cluster size; Unc., uncorrected; Operc., opercula; Op., operculum; HPC, hippocampus; Hypothal., hypothalamic; Med., medial; PFC, prefrontal cortex; Temp., temporal; Subg., subgenual; Preg., pregenual; ACC, anterior cingulate cortex; Dorsolat., dorsolateral.

Coordinates (X: Y: Z) are given in Montreal Neurological Institute Atlas space.